5-Fluorouracil, CAS [[51-21-8]]

Product Overview

• Article Name: 5-Fluorouracil, CAS [[51-21-8]]
• Biozol Catalog Number: FBM-10-1276
• Supplier Catalog Number: 10-1276
• Alternative Catalog Number: FBM-10-1276-250MG, FBM-10-1276-1G
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 5-Fluoro-1H,3H-pyrimidine-2,4-dione. Alternate Names: 5-FU

Product Description

Thymidylate synthase inhibitor

Product Properties

• Molecular Weight: 130.08
• Purity: 98%
• Form: White solid
• CAS Number: [51-21-8]
• Formula: C4H3FN2O2

Application Notes

• Application Notes: 5-Fluorouracil (5-FU) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-FU are 5-Fluorodeoxyuridylate (5-FdUMP), 5-Fluorodeoxyuridine triphosphate (5-FdUTP) and 5-Fluorouridine triphosphate (5-FUTP). The primary cytotoxic effect of 5-FU is believed to be inhibition of thymidylate synthase by 5-FdUMP. Secondary effects include incorporation of 5-FdUTP into DNA resulting in DNA strand breaks and incorporation of 5-FUTP into RNA causing abnormal RNA processing.1