Chemical Name: 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
HAT inhibitor
Molecular Weight:
445.44
Purity:
98% by TLC, NMR conforms
Form:
Orange solid
CAS Number:
[328968-36-1]
Formula:
C24H19N3O6
Application Notes:
Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.
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