Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Porcn inhibitor: Wnt/b-catenin pathway inhibitor
Molecular Weight:
466.61
Purity:
98% by TLC, NMR (Conforms)
Form:
Beige solid
CAS Number:
[686770-61-6]
Formula:
C22H18N4O2S3
Application Notes:
IWP-2 is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50=27nM) by inhibition of the O-acyltransferase Porcn1. Induces cardiomyocyte differentiation from human pluripotent stem cells2. An important tool to probe the involvement of the Wnt pathway in physiological processes3,4. Cell permeable.
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