Chemical Name: N-Benzyloxycarbonyl-L-phenylalaninylchloromethyl ketone. Alternate Names: ZPCK
p53/mdm2 inhibitor
Molecular Weight:
331.80
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[26049-94-5]
Formula:
C18H18ClNO3
Application Notes:
Inhibits the p53-MDM2 interation (20 µM).1 Alkylates one catalytic histidine residue (His-397) participating in the charge-relay system of carboxypeptidase Y.2 Has also been shown to inhibit bovine chymotrypsin A-gamma. A potent inhibitor of the severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), Ki=306 nM.3
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