BIX-01294, CAS [[935693-62-2]]

Product Overview

• Article Name: BIX-01294, CAS [[935693-62-2]]
• Biozol Catalog Number: FBM-10-1335
• Supplier Catalog Number: 10-1335
• Alternative Catalog Number: FBM-10-1335-5MG, FBM-10-1335-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride

Product Description

Histone Methyl transferase inhibitor+D257

Product Properties

• Molecular Weight: 600.02
• Purity: >98% by HPLC
• Form: Off-white solid
• CAS Number: [935693-62-2]
• Formula: C28H38N6O2

Application Notes

• Application Notes: BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase, IC50 = 1.7 µM) as well as GLP HMTase (IC50 = 38 µM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in vitro.1 BIX-01294 facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells.3