Chemical Name: (2S.3S)-trans-Epoxy succinyl-L-leucylamido-(4-guanidino) butane
Cysteine protease inhibitor
Molecular Weight:
357.41
Purity:
98% by HPLC NMR (Conforms)
Form:
White or off-white solid
CAS Number:
[66701-25-5]
Formula:
C15H27N5O5
Application Notes:
Cell-permeable, epoxysuccinyl peptide irreversible inhibitor of calpain and other cysteine proteases.1,2 Inhibits calpain-dependent apoptosis pathway in T cells3 but promotes heat-induced apoptosis in FM3A cells. Typical working concentration is 0.5-10 µg/ml.4
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