JQ1 (+/-), CAS [[1268524-69-1]]

Product Overview

• Article Name: JQ1 (+/-), CAS [[1268524-69-1]]
• Biozol Catalog Number: FBM-10-1361
• Supplier Catalog Number: 10-1361
• Alternative Catalog Number: FBM-10-1361-5MG, FBM-10-1361-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester

Product Description

Bromodomain inhibitor

Product Properties

• Molecular Weight: 457.00
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [1268524-69-1]
• Formula: C23H25ClN4O2S

Application Notes

• Application Notes: JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers1.