Irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-gamma-lyase. It inhibits H2S production in rat liver preparations (IC50=55 µM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. It reduces inflammation in a rodent carrageenan-induced hindpaw edema model3. Ameliorates gentamycin-induced nephrotoxicity1.
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