Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride. Alternate Names: F6
DUB inhibitor
Molecular Weight:
339.86
Purity:
98% by HPLC, NMR (conforms)
Form:
Yellow solid
CAS Number:
[157654-67-6]
Formula:
C21H21NO HCl
Application Notes:
A pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 µM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway1,2. Cell permeable.
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