Chemical Name: N-[6-(4-chlorophenoxy)hexyl]-N-cyano-N-4-pyridinyl-guanidine. Alternate Names: GMX-1778
NAMPT inhibitor
Molecular Weight:
371.86
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[200484-11-3]
Formula:
C19H22ClN5O
Application Notes:
A potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD.1 Displays potent cytotoxic effects in tumor cells.2,3 Displays antitumor activity in vivo.3 Increases ROS levels in cancer cells but not in normal cells.4
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