A potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD.1 Displays potent cytotoxic effects in tumor cells.2,3 Displays antitumor activity in vivo.3 Increases ROS levels in cancer cells but not in normal cells.4
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