Chemical Name: N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
Hedgehog pathway antagonist
Molecular Weight:
550.71
Purity:
98% by TLC, NMR (Conforms)
Form:
Tan solid
CAS Number:
[334998-36-6]
Formula:
C31H42N4O5
Application Notes:
Novel Hedgehog signaling pathway inhibitor (IC50=100-200 nM). Selectively binds to Smo but not other GPCRs. Blocks the formation of and induces the regression of basaloid lesions in skin punches and shrinks UV-induced basaloid lesions in adult mouse skin. Cell permeable.
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