Chemical Name: 4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine. Alternate Names: LY-2584702
S6K inhibitor
Molecular Weight:
445.42
Purity:
97% by HPLC, NMR (conforms)
Form:
Yellow solid
CAS Number:
[1082949-67-4]
Formula:
C21H19F4N7
Application Notes:
A selective inhibitor of the p70 ribosomal S6 kinase (S6K)1. Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 µM with no activity at GSK3beta and Erk1/2 at 10 µM2. Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K2. Cell permeable.
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