Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
PDE11 inhibitor
Molecular Weight:
304.44
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[686770-80-9]
Formula:
C15H16N2OS2
Application Notes:
A potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 µM).1 IC50s for PDE1-10 are greater than 100 µM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2
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