KL-001, CAS [[309928-48-1]]

Product Overview

• Article Name: KL-001, CAS [[309928-48-1]]
• Biozol Catalog Number: FBM-10-1411
• Supplier Catalog Number: 10-1411
• Alternative Catalog Number: FBM-10-1411-5MG, FBM-10-1411-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide

Product Description

Cryptochrome (CRY) activator

Product Properties

• Molecular Weight: 398.46
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [309928-48-1]
• Formula: C21H22N2O4S

Application Notes

• Application Notes: A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes1. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure2. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.