Chemical Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinolone-2,7-dione
p90 RSK inhibitor: insulin stimulator
Molecular Weight:
366.42
Purity:
98% by TLC, NMR (Conforms)
Form:
Brown solid
CAS Number:
[376382-11-5]
Formula:
C24H18N2O2
Application Notes:
Inhibits p90 ribosomal S6 kinase (RSK), IC50 = 1.2, 1.5 and 2.4 µM for RSK3, RSK1 and RSK2 respectively1. Induces a beta-cell-like state in pancreatic apha-cells and induces insulin expression1,2. Increases the endocrine cell content and function of donor human pancreatic islets in culture1. Blocks muscarinic acetylcholine receptor-stimulated RSK activation and subsequent proliferation of SNU-407 colon cancer cells3.
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