Chemical Name: 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
LPA2 antagonist
Molecular Weight:
391.44
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[325850-81-5]
Formula:
C22H17NO6S
Application Notes:
Selective agonist of the lysophosphatidic acid - 2 (LPA2) receptor. Displays antiapoptotic activity.1 Rescues apoptotically condemned cells from death and injury caused by high-dose gamma-irradiation in vitro and in vivo. Rescues mice from deadly levels of radiation when given 24 hours post-exposure.2 Activates the ERK1/2 prosurvival pathway.2
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