Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone
TRPA1 channel activator
Molecular Weight:
315.41
Purity:
98% by TLC, NMR (Conforms)
Form:
Tan solid
CAS Number:
[348575-88-2]
Formula:
C15H13N3OS2
Application Notes:
Reversible, photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 µM) and mice, in vivo. Photodetection is performed by sensory neurons expressing the TRPA1 cation channel which is activated via structure-dependent photochemical reactions with redox-sensitive cysteine residues.1
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