Effectively disables c-Myc by inhibiting the c-Myc-Max associationn and function1. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells2. Induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia3. Inhibits the MYCN/Max interaction leading to cell cycle arrest, apoptosis and neuronal differentiation in MYCN-amplified neuroblastoma cells4.
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