GPI-16552, CAS [[443794-40-9]]

Product Overview

• Article Name: GPI-16552, CAS [[443794-40-9]]
• Biozol Catalog Number: FBM-10-1502
• Supplier Catalog Number: 10-1502
• Alternative Catalog Number: FBM-10-1502-5MG,FBM-10-1502-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

PARG inhibitor

Product Properties

• Molecular Weight: 502.62
• Purity: 98% by TLC, NMR (conforms)
• Form: Pale yellow solid
• CAS Number: [443794-40-9]
• Formula: C33H30N2O3

Application Notes

• Application Notes: A novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 µM1. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia2. It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model3 and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma4. Synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells5.