PD-150606, CAS [[179528-45-1]]

Product Overview

• Article Name: PD-150606, CAS [[179528-45-1]]
• Biozol Catalog Number: FBM-10-1515
• Supplier Catalog Number: 10-1515
• Alternative Catalog Number: FBM-10-1515-5MG, FBM-10-1515-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid

Product Description

Calpain inhibitor

Product Properties

• Molecular Weight: 306.12
• Purity: 98% by TLC, NMR (Conforms)
• Form: Yellow solid
• CAS Number: [179528-45-1]
• Formula: C9H7IO2S

Application Notes

• Application Notes: A selective, cell-permeable non-peptide calpain inhibitor (Ki for µ- and m-calpains = 0.21 and 0.37 µM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices1. Displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death2. Some protective effects may be due to inhibition of MMP activity3.