Chemical Name: 1,1-Decamethylenebis(4-aminoquinaldinium)dichloride. Alternate Names: Dequalinium chloride, MB12, DECA
Mitochondrial import inhibitor
Molecular Weight:
527.58
Purity:
>98% by TLC NMR (Conforms)
Form:
Beige solid
CAS Number:
[522-51-0]
Formula:
C30H40Cl2N4
Application Notes:
Attenuates mitochondrial protein import (4-10 uM). Discovered in a screen of FDA-approved drugs. Blocks translocation of a mutant form of alanine: glyoxylate aminotransferase (AGT) to the mitochondria and restores AGT trafficking to peroxisomes.1 Also reduces oxalate accumulation and thus has potential to treat patients with primary hyperoxaluria 1 who possess mutations in AGT.1 Also displays antimicrobial activity2, inhibits apamin-sensitive K+ channels3 and induces apoptosis by inhibiting XIAP4.
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