L524-0366, CAS [[951612-19-4]]

Product Overview

• Article Name: L524-0366, CAS [[951612-19-4]]
• Biozol Catalog Number: FBM-10-1536
• Supplier Catalog Number: 10-1536
• Alternative Catalog Number: FBM-10-1536-5MG,FBM-10-1536-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Fn14 antagonist

Product Properties

• Molecular Weight: 308.79
• Purity: 98% by TLC, NMR (Conforms)
• Form: Beige solid
• CAS Number: [951612-19-4]
• Formula: C13H13ClN4OS

Application Notes

• Application Notes: Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 µM). It specifically inhibits TWEAK-Fn14-mediated NFkappaB activation. It completely suppressed TWEAK-induced T98G cell migration (10 µM) without cytotoxicity up to 50 µM1. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics2.