Chemical Name: 2-(3,2-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one. Alternate Names: 3,4-Dimethoxy-alpha-naphthoflavone
AhR modulator (SAhRM)
Molecular Weight:
332.45
Purity:
99% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[14756-24-2]
Formula:
C21H16O4
Application Notes:
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression1. Represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation2. Represses estrogen-inducible transcription3.
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