Chemical Name: 3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrol-2,5-dione hydrochloride. Alternate Names: BIM X, Bisindolylmaleimide X
PKC inhibitor
Molecular Weight:
460.96
Purity:
98% by TLC, NMR (Conforms)
Form:
Red solid
CAS Number:
[145317-11-9]
Formula:
C26H24N4O2 HCl
Application Notes:
Selective, reversible, ATP-competitive inhibitor of protein kinase C. Inhibits PKCalpha, beta1, beta2, gamma and epsilon, IC50= 8, 8, 14,13 and 39 nM respectively.1 Extremely useful tool for probing PKC-dependent physiology2 or signaling pathways3. Increases MSC adhesion to an ICAM-1 coated substrate in vitro and enables targeted delivery of systematically administered MSCs to inflamed sites in vivo in a CD11a-dependent manner.4 Cell permeable.
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