Chemical Name: 5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
EPAC inhibitor
Molecular Weight:
367.21
Purity:
98% by TLC, NMr (Conforms)
Form:
Orange-red solid
Formula:
C15H8Cl2N2O3S
Application Notes:
An allosteric inhibitor of Epac1, IC50= 4 µM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2
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