Chemical Name: 3-(5-Hydroxymethyl-2-furyl)-1-benzylindazole. Alternate Names: Lificiguat
Soluble guanylyl cyclase activator
Molecular Weight:
304.34
Purity:
98% by HPLC NMR (Conforms)
Form:
Pink solid
CAS Number:
[170632-47-0]
Formula:
C19H16N2O2
Application Notes:
Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of rabbit platelets (IC50 = 14.6 µM).1 Induces human endometrial cancer cell senescence via modulation of HIF1 activity.2 Induces degradation of HIF13 Protects against glutamate-induced neuronal damage4 and -amyloid-induced toxicity in differentiated PC12 cells5.
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