Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of rabbit platelets (IC50 = 14.6 µM).1 Induces human endometrial cancer cell senescence via modulation of HIF1 activity.2 Induces degradation of HIF13 Protects against glutamate-induced neuronal damage4 and -amyloid-induced toxicity in differentiated PC12 cells5.
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