JQ1 (+), CAS [[1268524-70-4]]

Product Overview

• Article Name: JQ1 (+), CAS [[1268524-70-4]]
• Biozol Catalog Number: FBM-10-1584
• Supplier Catalog Number: 10-1584
• Alternative Catalog Number: FBM-10-1584-5MG, FBM-10-1584-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester

Product Description

BET Bromodomain inhibitor

Product Properties

• Molecular Weight: 456.99
• Purity: 98% by HPLC NMR conforms
• Form: White solid
• CAS Number: [1268524-70-4]
• Formula: C23H25ClN4O2S

Application Notes

• Application Notes: Potent BET bromodomain inhibitor and is the active isomer. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively (data for + isomer).1 Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.1 Induces squamous differentiation in NMC cell lines and inhibits tumor growth in NMC xenografts.2 Displays reversible contraceptive effects in male mice.3 Blocks inflammation and bone loss in periodontitis.4 Reverses CAR T cell extinction.5