Chemical Name: N-Oleoyl Phe. Alternate Names: NOPA, C18-1-Phe
Endogenous uncoupler of mitochondrial respiration
Molecular Weight:
429.64
Purity:
99% by TLC, NMR (Conforms)
Form:
Off-white solid
CAS Number:
[136560-78-6]
Formula:
C27H43NO3
Application Notes:
An endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler of UCP1-independent respiration and is the most potent in the group of structurally different lipoamino acids evaluated. Mice treated with an analog, C18-1-Leu, were found to have improved glucose homeostasis and increased energy expenditure.1
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