Chemical Name: 1-Methyl-3,4-bis(indol-3-yl)maleimide. Alternate Names: Bisindolylmaleimide V, BIM V
p70 S6 Kinase inhibitor
Molecular Weight:
341.36
Purity:
98% by TLC, NMR (Conforms)
Form:
Orange solid
CAS Number:
[113963-68-1]
Formula:
C21H15N3O2
Application Notes:
This bis indolylmaleimide derivative is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1 Does not inhibit PKC (at concentrations <100 µM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4.
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