Chemical Name: (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-pentanamido]butanoic acid. Alternate Names: CGP-48933
Angiotensin antagonist
Molecular Weight:
435.52
Purity:
99% by TLC, NMR (conforms)
Form:
White solid
CAS Number:
[137862-53-4]
Formula:
C24H29N5O3
Application Notes:
High affinity angiotensin AT1 receptor antagonist (Ki = 2.38 nM). Highly selective (30,000-fold) over AT2 receptors1,2. Normalizes the increased production of inflammatory cytokines in adipose and liver tissue in LPS-infused mice3. Clinically useful antihypertensive agent. Orally active.
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