Fatty acid synthase (FAS) inhibitor. Binds to beta-keto-acyl-ACP synthase (KAS, IC50=1.5 µM), thus inhibiting protein acylation at concentrations of 45-134 µM1. Produces metabolic effects similar to the effects of leptin, but through mechanisms that are independent of, or down-stream of, both leptin and melanocortin receptors2. Reduces nutrient-induced insulin release from normal rat islets3. Induces apoptosis in human melanoma A-375 cells4.
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