Chemical Name: Fermentation product from Penicillium citreoviride
Mitochondrial and ectopic ATPase inhibitor
Molecular Weight:
420.49
Purity:
>98% by HPLC NMR (Conforms)
Form:
Yellow solid
CAS Number:
[25425-12-1]
Formula:
C23H30O6
Application Notes:
Citreoviridin is a mycotoxin produced by Penicillium and Aspergillus species.1 It is an inhibitor of both the mitochondrial (Ki = 4.5 µM)2 and ectopic ATPase3 and selectively suppresses the growth and proliferation of lung cancer cells without affecting normal cells3. It induces liver fibrosis in mice4 and induces autophagy-dependent apoptosis through the lysosomal-mitochondria axis in human liver cells5. Low concentrations of citreoviridin prevent both calcium deposition in vascular smooth muscle cells and osteoclast activation in vitro.6
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