Chemical Name: 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one. Alternate Names: Clavacin, Mycoin, Penicidin, Terinin, NSC8120
Oxidative- and ER-stress inducer
Molecular Weight:
154.12
Purity:
98% by HPLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[149-29-1]
Formula:
C7H6O4
Application Notes:
A mycotoxin found in contaminated fruits. Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to several organs including liver and kidney in laboratory animals.3 Triggers NRF2-mediated survival mechanisms in kidney cells.4 Induces apoptosis through a ROS-mediated ER stress pathway.5
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