Chemical Name: N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide. Alternate Names: BMS-354825
Src and Bcr/Abl inhibitor
Molecular Weight:
488.01
Purity:
98% by TLC, NMR (Conforms)
Form:
White or off-white solid
CAS Number:
[302962-49-8]
Formula:
C22H26ClN7O2S
Application Notes:
Inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively1,2. Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells3.
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