Chemical Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose. Alternate Names: Streptozocin, U-9889
Diabetes inducer
Molecular Weight:
265.22
Purity:
97% by TLC, NMR (Conforms)
Form:
Off-white solid
CAS Number:
[18883-66-4]
Formula:
C8H15N3O7
Application Notes:
An N-nitroso-aminoglucose derivative which is used to produce animal models of diabetes.1 Alkylates DNA.2 Inhibits pancreatic beta-cell O-Glc-NAc selective N-acetyl-beta-D-glucosaminidase.3 Selectively induces death of beta-cells which mechanistically is independent of N-acetyl-beta-D-glucosaminidase inhibition.4 Is not a spontaneous NO donor.5
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