Erlotinib HCl, CAS [[183319-69-9]]

Product Overview

• Article Name: Erlotinib HCl, CAS [[183319-69-9]]
• Biozol Catalog Number: FBM-10-2135
• Supplier Catalog Number: 10-2135
• Alternative Catalog Number: FBM-10-2135-10MG, FBM-10-2135-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride

Product Description

EGFR Kinase inhibitor

Product Properties

• Molecular Weight: 429.91
• Purity: 98% by TLC, NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [183319-69-9]
• Formula: C22H23N3O4 HCl

Application Notes

• Application Notes: Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM)1. Potent inhibitor of mutant JAK2-V617F2. Weaker inhibitor of ErbB-2 kinase (Ki = 1 µM) ErbB-4 kinase (Ki = 1.5 µM)3. HDAC inhibitors sensitize for erlotinib activity in EGFR-mutated and wildtype non-small cell lung cancer (NSCLC) cells4. A clinically effective agent for NSCLC5.