Chemical Name: (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide. Alternate Names: LBH-589
HDAC inhibitor
Molecular Weight:
349.44
Purity:
98% by TLC, NMR (Conforms)
Form:
Off-white solid
CAS Number:
[404950-80-7]
Formula:
C21H23N3O2
Application Notes:
A potent inhibitor of class I and II HDACs1. Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells2. A potent antimyeloma agent that overcomes drug resistance3.
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