Pazopanib, CAS [[444731-52-6]]

Product Overview

• Article Name: Pazopanib, CAS [[444731-52-6]]
• Biozol Catalog Number: FBM-10-2158
• Supplier Catalog Number: 10-2158
• Alternative Catalog Number: FBM-10-2158-10MG, FBM-10-2158-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide. Alternate Names: GSK-VEG10003, GW786034B

Product Description

Multi-receptor tyrosine kinase inhibitor

Product Properties

• Molecular Weight: 437.52
• Purity: >98% by HPLC NMR (Conforms)
• Form: White to off-white solid
• CAS Number: [444731-52-6]
• Formula: C21H23N7O2S

Application Notes

• Application Notes: Inhibits multiple receptor tyrosine kinases including VEGFR1,2 and 3 (IC50s=10, 30, 47 nM respectively) and PDGFRalpha, beta and c-Kit (IC50s=71, 84, 74 nM respectively) and others such as FGFR.1 The drug targets both the tumor and endothelial cells in a mouse xenograft model of human multiple myeloma.2 It reduces joint pain and inhibits cartilage degeneration in rodent osteoarthritis models.3 VEGF inhibitors such as pazopanib have potential for treatment of neovascular age-related macular degeneration.4 In clinical use for renal cell carcinoma.5