Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one. Alternate Names: 2-Amino-3-methoxyflavone
MEK inhibitor
Molecular Weight:
267.29
Purity:
98% by TLC, NMR conforms
Form:
Yellow solid
CAS Number:
[167869-21-8]
Formula:
C16H13NO3
Application Notes:
Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7M).1,2 Accelerates differentiation of RAW264.7 cells into osteoclast-like cells.3 Mimics BMP4 in supporting self renewal of embryonic stem cells4.
10-2159
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