SB 203580, CAS [[152121-47-6]]

Product Overview

• Article Name: SB 203580, CAS [[152121-47-6]]
• Biozol Catalog Number: FBM-10-2173
• Supplier Catalog Number: 10-2173
• Alternative Catalog Number: FBM-10-2173-5MG, FBM-10-2173-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazole

Product Description

p38 MAP kinase inhibitor

Product Properties

• Molecular Weight: 377.44
• Purity: 98% by TLC, NMR (conforms)
• Form: Off-white solid
• CAS Number: [152121-47-6]
• Formula: C21H16N3OSF

Application Notes

• Application Notes: A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38beta2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38gamma and delta at 10 µM2. A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function3.