ZSTK474, CAS [[475110-96-4]]

Product Overview

• Article Name: ZSTK474, CAS [[475110-96-4]]
• Biozol Catalog Number: FBM-10-2180
• Supplier Catalog Number: 10-2180
• Alternative Catalog Number: FBM-10-2180-5MG, FBM-10-2180-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-(2-Difluoromethylbenzoimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine

Product Description

PI 3-kinase inhibitor

Product Properties

• Molecular Weight: 417.41
• Purity: 99% by HPLC NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [475110-96-4]
• Formula: C19H21F2N7O2

Application Notes

• Application Notes: Novel Class I phosphatidylinositol 3-kinase (PI3K) inhibitor. ZSTK474 is an ATP-competitive inhibitor of all four Class I PI3K isoforms. However, it inhibits PI3Kdelta most potently, with a Ki of 1.8 nM, while inhibiting the alpha, beta and gamma isoforms at slightly higher concentrations (6.7 nM, 10.4 nM and 11.7 nM, respectively)1. Displays potent antitumor activity against human cancer xenografts (A549, PC-3 and WiDr) when administered to mice2. It displays potent anti-inflammatory activity via modulation of human CD14+ monocyte-derived dendritic cell functions and suppresses experimental autoimmune encephalomyelitis3. Ameliorates the progression of adjuvant-induced arthritis in a rat model4.