Chemical Name: 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10.11-dione
AP-1 transcription factor inhibitor
Molecular Weight:
294.35
Purity:
98% by TLC, NMR conforms
Form:
Orange solid
CAS Number:
[568-72-9]
Formula:
C19H18O3
Application Notes:
Diterpenoid naphthoquinone found in Salvia sp. and isolated as an active component of the traditional Chinese medicine Tanshen. Tanshinone IIA displays anti-inflammatory activity1 and induces apoptosis in a variety of cell lines2. Also inhibits AP-1 activity by suppressing jun-fos-DNA complex formation (IC50 = 0.22 µM)3.
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