Gambogic acid, CAS [[2752-65-0]]

Product Overview

• Article Name: Gambogic acid, CAS [[2752-65-0]]
• Biozol Catalog Number: FBM-10-2188
• Supplier Catalog Number: 10-2188
• Alternative Catalog Number: FBM-10-2188-5MG,FBM-10-2188-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Survivin inhibitor

Product Properties

• Molecular Weight: 628.75
• Purity: 98% by TLC, NMR (Conforms)
• Form: Orange solid
• CAS Number: [2752-65-0]
• Formula: C38H44O8

Application Notes

• Application Notes: Induces apoptosis in a variety of cell lines acting as an antagonist of Bcl-2 family proteins (IC50 < 1 µM)1, however additional targets may contribute to its cytotoxicity. It suppresses cancer invasion and migration by inhibiting TGFbeta1-induced epithelial-to-mesenchymal transition.2 Potentiates the chemosensitivity of cancer cells to other agents.3 Down-regulates surviving, reversing docetaxel resistance in cancer cells.4

Images

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