Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
K-ATP channel activator
Molecular Weight:
230.67
Purity:
99% by HPLC, NMR (Conforms)
Form:
White solid
CAS Number:
[364-98-7]
Formula:
C8H7ClN2O2S
Application Notes:
Activates ATP-dependent K+ channels1 via inducing translocation of PKC-epsilon from the cytosol to the mitochondria2. Hyperglycemic agent. Induces powerful protective effects against cardiac ischemia via multiple mechanisms.3 Stimulates mitochondrial ATP synthase activity conferring cardioprotection in a streptozotocin-induced acute diabetes model.4 Prevents alterations in memory and synaptic plasticity induced by Amyloid-ß.5
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