L-Cycloserine, CAS [[339-72-0]]

Product Overview

• Article Name: L-Cycloserine, CAS [[339-72-0]]
• Biozol Catalog Number: FBM-10-2280
• Supplier Catalog Number: 10-2280
• Alternative Catalog Number: FBM-10-2280-20MG, FBM-10-2280-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (S)-4-Amino-3-isoxaolidinone. Alternate Names: L-(-)-Cycloserine, S-Cycloserine

Product Description

Sphingolipid biosynthesis inhibitor

Product Properties

• Molecular Weight: 102.09
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [339-72-0]
• Formula: C3H6N2O2

Application Notes

• Application Notes: L-Cycloserine down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4