Chemical Name: N-p-Tosyl-L-phenylalanine chloromethyl ketone
Serine protease inhibitor
Molecular Weight:
351.80
Purity:
98% by TLC, NMR Conforms
Form:
White solid
CAS Number:
[402-71-1]
Formula:
C17H18ClNO3S
Application Notes:
TPCK is an irreversible inhibitor of the serine protease chymotrypsin.1 It also inhibits certain cysteine proteases (bromelain, ficin, papain).1 TPCK inhibited (IC50 = 5 µM) the mitogen-induced activation of pp70s6k, a mitogen-regulated serine/threonine kinase involved in the G1 to S phase transition of the cell cycle.2
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