Chemical Name: 3,5-Diallyl-[1,1-biphenyl]-2,4-diol. Alternate Names: NSC-293100
SIRT3 activator
Molecular Weight:
266.34
Purity:
>98% TLC/GC NMR (Conforms)
Form:
Beige solid
CAS Number:
[35354-74-6]
Formula:
C18H18O2
Application Notes:
Honokiol is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.1 It reversed cardiac hypertrophy in mice1 and rescued myocardial and mitochondrial energetics in type 2 diabetic rats2. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.3 It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.4
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