Chemical Name: (1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate. Alternate Names: TVP-1012, Azilect
MAO-B inhibitor, Neuroprotective
Molecular Weight:
267.34
Purity:
99% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[161735-79-1]
Formula:
C12H13N CH3SO3H
Application Notes:
Potent, irreversible monoamine oxidase (MAO) inhibitor selective for MAO-B (IC50=4.43 nM) over MAO-A (IC50=412 nM).1 Parkinsons disease therapeutic.2 Displays neuroprotective and neurorestorative properties in a Parkinsons disease zebrafish model.3 Prevents -synuclein-induced dopaminergic neuronal death and rescues TrkB neurotrophic signaling.4 Enhances BDNF levels and is neuroprotective in Parkinsons disease models.5
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