alpha1- and alpha2B-adrenoceptor antagonist (Ki = 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for alpha1A, alpha1B, alpha1D, alpha2B, alpha2A and alpha2C receptors respectively)1. Displays antihypertensive activity2. Improves glucose and lipid metabolism in hypertensives3. Displays antiangiogenic activity in human prostate cancer and endothelial cells4. Activates Pgk1 and Hsp90 to promote stress resistance5. Active in vivo.
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