Halofuginone HBr, CAS [[64924-67-0]]

Product Overview

• Article Name: Halofuginone HBr, CAS [[64924-67-0]]
• Biozol Catalog Number: FBM-10-2381
• Supplier Catalog Number: 10-2381
• Alternative Catalog Number: FBM-10-2381-10MG, FBM-10-2381-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2R,3S)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide. Alternate Names: NSC 713205

Product Description

Prolyl-tRNA synthase inhibitor

Product Properties

• Molecular Weight: 495.60
• Purity: >98% by TLC NMR (Conforms)
• Form: White solid
• CAS Number: [64924-67-0]
• Formula: C16H17BrClN3O3 HBr

Application Notes

• Application Notes: Potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-beta signaling, including reversibly reducing Smad3 protein levels and inhibiting fibroblast differentiation.2 Blocks fibrosis, angiogenesis, and tumor progression.2,3 Inhibition of PRS results in amino acid starvation which activates the integrated stress response (ISR) and mTOR signaling4 and thus preventing differentiation of TH17 cells, suppressing the autoimmune response5. Reduces TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation, limiting SARS-CoV-2 cellular entry.6